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Hopefully well get endorsements from NICE for high cardiovascular risk, in which case its going to open up potentially quite a large cohort of individuals who will be eligible and derive benefit. We should definitely be reviewing all of this rapidly, adds Ruszala, who is particularly interested in the potential anti-inflammatory properties of GLP-1s
The treatment of T2D has shifted from a gluco-centric approach to a broader cardio-renal-metabolic strategy, emphasizing the prevention of cardiovascular and renal events and the improvement of metabolic aspects beyond glucose control such as promoting weight loss
GLP-1 induces FNDC5 expression in pancreatic -cells via CREB promoting the conversion of WAT to BAT and thereby enhancing energy metabolism [1]
JAMA, 314(7), 687-699
