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I think most people think about these processes in terms of a single, ideal bound conformation of the peptide to the receptor as the basis for signalling, says Gellman, but Im increasingly suspecting that certain modes of dynamics are critical for signalling. He is now trying to design this structural variability into his hybridtides to see if this will improve on the performance of GLP-1 drugs

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Despite promising findings from preclinical and observational clinical studies, challenges persist

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia

J Biol Chem 278:4114841159