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Other recent studies include: The American College of Cardiology 2021 Semaglutide Treatment Effect in People With Obesity STEP 1 Conclusions: Among obese patients, the GLP-1 analogue semaglutide plus lifestyle intervention was superior to placebo plus lifestyle intervention at improving weight loss. The New England Journal of Medicine 2021 Once-Weekly Semaglutide in Adults with Overweight or Obesity Conclusions: In participants with overweight or obesity, 2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight. Struggling with Weight Loss Every day, millions of people around the world rely on modern medical advancements to maintain their health and well-being