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Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked

Meanwhile, orforglipron demonstrated significant weight loss efficacy [8] consistent with injectable GLP-1 medicines

Worried about hair thinning on GLP-1 meds