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However, this landscape could shift next year with the anticipated approval of: The oral version of Wegovy for obesity treatment (approved just yesterday) Eli Lillys Orforglipron

While expensive relative to other agents, these classes of drugs are generally cost-effective as second-line treatment, although cost-effectiveness data are limited

Alternatively, using a 20mg vial with 2ml produces a 10mg/ml solution where even 12mg requires only 1.2ml, fitting comfortably in a standard insulin syringe

They also work best when combined with nutritional and lifestyle changes

Resmetirom, the first FDA-approved drug for MASH: from drug discovery and action mechanisms to clinical trials