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Adequate water intake, fiber, and in some cases stool softeners help manage this
SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), significant on 4-point MACE (0.88) and all-cause death (0.84): Heerspink SURPASS-4 kidney post-hoc
If a patient develops persistent vomiting, severe abdominal pain, or any symptom that worries them, they have a physician who knows their history, their dose, and their full clinical context
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None of these indicators are definitive on their own
