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Tirzepatide, the active ingredient in Mounjaro and Zepbound, is a 39-amino acid dual agonist targeting both GLP-1 and GIP receptors, also incorporating a fatty acid modification for half-life extension, and is the most commercially significant synthetic peptide ever produced at scale

This tissue absorbs semaglutide erratically and can reduce the medications effectiveness

And when problems do occur, I don't think it's the drug itself causing issues with healing, says Dr

GLP-1 medications accounted for 5.4% of all American adult prescriptions in September 2024, up from 3.5% in 2023

Michos, MD, MHS, FACC, FAHA, FASE, FASPC, can be reached at [email protected]