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To maintain GSCs and proliferative cell fate, GLP-1/Notch activity must remain above a threshold for proliferation/differentiation decision

Human studies discovered that metformin promoted mitochondrial respiratory chain activity in various tissues [73,74]

Although GLP-1s have seen incredible successes, there are still issues with tolerability issues and access not to mention opportunities for more convenient formulations

But they are changing the landscape of medicine because they hit a fundamental biology we have ignored for too long: the gut-brain-metabolic axis

Moreover, the duration of impact on gastrin secretion after stopping medication is markedly different due to differences in pharmacokinetic profiles