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Some states have expanded coverage to include weight management indications, while others restrict coverage to diabetes treatment only or require prior authorization

[5] [6] Dehydration and reduced fluid intake represent one of the most common contributing factors

Nausea is common, especially during dose increases

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It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue