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The other author has no conflicts of interest related to this publication

Retatrutide (LY3437943) is an investigational GLP-1, GIP, and glucagon triple receptor agonist currently in Phase 2 clinical trials

Animal research suggests that intestinal NAD+ biosynthesis is required for the gut to produce GLP-1 naturally, though human data is still emerging

Hypoglycemia : If youre on other diabetes medications, you might experience low blood sugar levels

What's New: TRIUMPH-1 Announced (May 21, 2026) Results announced: May 21, 2026 Eli Lilly press release Trial status: Complete all primary and key secondary endpoints met Key result: 28.3% average weight loss at 80 weeks (12mg dose, N=2,339) NDA impact: Eli Lilly now has the primary efficacy dataset required for Q4 2026 NDA filing Next trial to watch: TRIUMPH-2 (diabetes) expected Q3Q4 2026 Introduction On May 21, 2026, Eli Lilly announced the topline results of TRIUMPH-1 the pivotal Phase 3 trial that determines whether retatrutide will receive FDA approval for obesity treatment