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Patients with certain rs6923761 polymorphisms may experience more pronounced initial gastrointestinal effects, though this typically diminishes with dose titration

This pharmacologic distinction provides a biologically plausible framework for why several long-acting GLP-1RAs demonstrate directionally favourable stroke estimates, whereas short-acting lixisenatide in a post-ACS population did not reduce stroke incidence in ELIXA [46]

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The more precise answer is that retatrutides safety is still being evaluated