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Understanding the Role of GLP-1 Agonists In addition to demonstrating weight loss benefits in adults with mood disorders including bipolar disorder, GLP-1 agonists such as liraglutide, tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy) have exhibited promising outcomes in addressing commonly associated metabolic concerns

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For instance, volagidemab (REMD-477), a monoclonal antibody targeting GCGR, has been shown to reduce insulin requirements and lower mean daily glucose by approximately 27 mg/dL over 24 hours in individuals with type 1 diabetes, without increasing the risk of hypoglycemia (58, 59)