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Medical monitoring of thyroid function, IGF-1, glucose, and clinical symptoms is mandatory, and comprehensive baseline testing should precede any attempt at combination therapy

pmid:23684677 4

A structured meal plan with GLP-1 alone may be more effective for sustainable weight loss and health

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These NMR data are in line with ligand-bound GLP-1R ECD crystal structures showing that the GLP-1 is a kinked but continuous -helix (Thr 13 Val 33 ), whereas the truncated exendin 939 is a straighter helix (Leu 10 -Lys 27 ) than GLP-1 when bound to GLP-1R (Runge et al., 2008
