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Heart rate increases were also noted at higher doses of retatrutide, another effect potentially linked to glucagon-mediated increases in metabolic rate
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Table 10: Effects of Dapagliflozin on the Systemic Exposures of Coadministered Drugs Clinical Studies Glycemic Control Trials In Adults With Type 2 Diabetes Mellitus The effectiveness of XIGDUO XR has been established in clinical trials of the coadministration of oral dapagliflozin and metformin HCl extended-release tablets in treatment-naive adult patients inadequately controlled on diet and exercise alone
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