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Even though semaglutide itself does not directly change how urine smells, the medication often leads to major shifts in eating patterns, appetite, and hydration

If you haven't lost weight by week four despite good medication adherence and dietary changes, contact your PlexusDx providerthey may recommend adjusting your dose, switching formulations, or adding complementary medications like tirzepatide ($279/mo) that target additional appetite-regulation pathways

Researchers have begun evaluating dulaglutide (Trulicity) for antidepressant effects in preclinical studies, suggesting that the drug class may eventually reach entirely new patient groups