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Patients often report initial gastrointestinal side effects, such as nausea and vomiting, which can be distressing and sometimes lead to discontinuation of the drug

The LEADER-derived CV risk prediction model predicted CV risk in the semaglutide data satisfactorily (the AUC [95% CI] of 0.77 [0.74;0.79] indicated a fair predictive performance [32]
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