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Consistent with CD-1 mouse PK data, intact AMG 133 has a shorter mean t 1/2,z compared to total AMG 133 (207 h versus 292 h)

These findings lay the groundwork for clinical translation, as discussed in the next section

Glucagon immunoreactivity and chromatographic profiles in pancreatectomized humans
Patients who maintain excellent digestive habits while on semaglutide experience very low recurrence rates compared to those with untreated constipation