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PCSK1/3 and PCSK2, PPCs subtypes in humans, perform the proteolytic cleavage of prohormones to their intermediate forms ( Brain and intestine GCG + cells are discovered to express PCSK1/3 while PCSK2 is expressed in the pancreas ( Figure 1 In 1966, Hopsu-Havu and Glenner discovered the existence of the enzyme dipeptidyl peptidase-4 (DPP-4) ( DPP4 gene

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