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Using a combination of chemogenetic, optogenetic, and pharmacological methods in wild-type and Glp-1Rdeficient mice, the authors delineated an NTS MHb IPN pathway responsible for nicotine avoidance

Delayed gastric emptying may undergo tachyphylaxis, potentially reducing the impact of DDIs with repeated dosing.169,174 Moreover, delayed absorption of the concomitant drug due to delayed gastric emptying can be minimized by administering the drug 1 h before GLP-1 RAs or a dual GLP-1/GIP RA administration.168 However, the possibility of DDIs related to delayed gastric emptying cannot be excluded,175 so investigators recommend monitoring when oral drugs are co-administered with GLP-1 RAs and a dual GLP-1/GIP RA