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The combination of GLP-1 receptor agonists and DPP-4 inhibitors is not recommended, not due to safety issues, but since a clinically significant additional benefit is not expected (see below) (7072)

The absence of a warning or notice for a given drug or drug combination does not indicate that the drug or drug combination is safe, appropriate, or effective for any given patient

January 2025: Ozempics warning label was updated to include severe pancreatitis and kidney injuries

Comprehensive Approach: The dual action of Tirzepatide addresses both blood sugar regulation and weight management, offering a holistic approach to improving health outcomes for our patients

They found that people who used GLP1-RAs had a slightly higher risk of being diagnosed with acne vulgaris within 90 days and one year after starting the medication