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Several factors may indicate its time to consider discontinuation: Stable health improvements: Some individuals achieve significant weight loss, improved glycemic control, or normalized blood pressure and lipid levels, which may reduce the clinical need for continued medication

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Trials of orforglipron and lower-dose tirzepatide suggest that if and when these drugs are licensed, they could be used to maintain weight loss after higher-dose injectable incretin therapies 45

Pharmacologic (very high) doses of lipoic acid have been found to decrease the activity of biotin-dependent carboxylases in rats, but such an effect has not been demonstrated in humans (72)