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The inhibition of intestinal glucose absorption is due to reduce the expression of SGLT1 on the apical membrane of jejunal enterocytes (Zubiaga et al., 2023)

For individuals with diabetes, who may already have altered nutrient metabolism, this can have important clinical implications

Decreased DPP-4 or CD26 expression is also seen in cases where CD9 is deleted and in murine models of hyperoxygenation [35]

18,19 The potential for more robust, structured nutrition and lifestyle therapy to mitigate weight gain after GLP-1 cessation has not been studied in controlled trials

Some people tolerate one medication better than another