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If protein intake is insufficient or you avoid strength training, you will lose more muscle along with fat , compromising your metabolic rate and physical appearance

That is standard for drugs still in Phase 2 and 3 development

Points of Interest in Trials Amycretins early trial data has been exceptionally promising, particularly in terms of weight loss outcomes: Phase I Oral Trial Weight Loss Results: Participants lost 10.4% of body weight over 12 weeks taking 50 mg daily