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Sustainable weight loss on semaglutide averages 1522% of body weight over 68 weeks in clinical trials, and this rate is maintained when patients prioritize adequate nutrition

The sample size in both ISAs provides at least 90% power to demonstrate superiority of tirzepatide to placebo for the mean percent change from baseline in AHI at a 2-sided alpha level of 0.05, assuming 50% improvement compared with placebo, with a common standard deviation of 50%, and up to 25% of participants discontinuing the study drug in each arm

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Not all patients experience side effects, and individual tolerability varies

Monitoring closely during dose increases is especially helpful, since most side effectsincluding palpitationsare more likely to appear when the dose changes