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Post-meal rebound?) #Diabetes #Tirzepatide #GLP1 #GIP #Glucagon #HepaticGlucoseOutput #T2D #CGM #MetabolicHealth #Endocrinology Dr Paramesh Shamanna

Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results

GLP-1 receptor agonists carry insufficient lactation safety data, and most healthcare providers recommend discontinuing before breastfeeding

The STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial programme demonstrated that adults using semaglutide 2.4 mg weekly alongside lifestyle intervention lost an average of approximately 15% of their body weight over 68 weeks, compared to around 2.4% with placebo. NICE approved Wegovy for use in specialist weight management services in the UK in 2023 (TA875), recognising its clinical effectiveness. Ongoing research continues to explore its cardiovascular benefits, with the SELECT trial showing a significant reduction in major cardiovascular events in people with obesity