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Despite the lack of GLP-1R expression, GLP-1RAs appear to have a positive effect on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), as evidenced by a clinical trial with liraglutide and now under further investigation in clinical trials with semaglutide (109, 110)

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Recent studies suggested that, albeit through different receptor pathways, irisin and GLP-1 activate the same intracellular signaling proteins, e.g

A walnut diet improves endothelial function in hypercholesterolemic subjects: A randomized crossover trial

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