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how were glp 1 agonists discovered Glucagon-like peptide-1 History of glucagon-like peptide-1 receptor
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189 ThomasMKNikooienejadABrayRCuiXWilsonJDuffinKet al

Importantly, this increase in insulin happens only when glucose levels rise (i.e., when the body needs insulin)

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an n-terminally truncated peptide that is a major endogenous metabolite in vivo

10.2337/db14-1577 72 ZhaiR.XuH.HuF.WuJ.KongX.SunX

Smaller, more frequent meals, avoiding high-fat foods during the adjustment period, and maintaining hydration all help manage GI discomfort
