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It depends on sustained receptor activation throughout the week
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doi:10.2337/diabetes.52.5.1147 197

Liraglutide treatment decreased the levels of superoxide dismutase (SOD) and reactive oxygen species (ROS), suggesting that liraglutide reduced oxidative stress in methygluoxal-induced SH-SY5Y cells

Most patients experience diarrhea for two to four weeks after starting semaglutide or increasing their dose