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Non-GLP-1 diabetes medications: If you do not tolerate or have an allergic reaction to a GLP-1-based medication, your doctor may recommend a non-GLP-1 medication for managing diabetes, such as metformin, SGLT2 inhibitors, or DPP-4 inhibitors

But even if money were not an issue, Hill says, there are a number of other factors that could lead patients to decide not to take GLP-1s long-term (see below)

Dose optimization may be appropriate if you have not reached the maximum tolerated dose according to FDA labeling (up to 15 mg weekly)