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Due to their lack of association with hypoglycemia, positive effects on satiety and weight loss, and infrequency of administration, these GLP-1 analogues are now the first injectable medication of choice indicated by ADA guidelines for type-2 diabetics

Current evidence indicates that semaglutide treatment is associated with some degree of lean body mass reduction, though this occurs as part of overall weight loss rather than through a direct muscle-wasting mechanism

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