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Semaglutide treatment in diabetic rats increased myocardial SOD activity by 35% and reduced malondialdehyde levels, a marker of lipid peroxidation, by 45% [77]

In a minority of cases it can lead to severe outcomes, including death

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[79] Trials for cardiovascular health [edit] In March 2024, the US Food and Drug Administration expanded the indication for semaglutide (brand name Wegovy) to reduce the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and who are either obese or overweight

To understand how these medications work, see GLP-1 Receptor Agonists Explained