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Counterintuitively, mice completely defective for the GLP-1 receptor were reported to be protected from high-fat diet-induced peripheral Insulin resistance (177) and, consistently with this, central inhibition of GLP-1R signaling with the antagonist exendin 9-39 improves glucose tolerance and glycaemia (178)

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[DOI] [PubMed] [Google Scholar] 626.Sonne D.P., Engstrom T., Treiman M

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Cigarette smoking is a leading cause of preventable death and disease in the USA, D bora Xavier, MD, teaching assistantprinciples and practice of clinical researchHarvard T.H