metformin vs glp 1 Full article: Will delayed release provide better management of diabetes type 2? GLP-1 vs. Metformin… let's simplify

Patients who received 5-mg injections lost roughly 12 pounds over 40 weeks, while patients who received 15 mg lost about 23 pounds of body weight

A reduced risk of major adverse cardiovascular events (MACE) was reported in CVOTs for T2DM for dulaglutide [AWARD-7 (NCT01621178)] [53], liraglutide [LEADER (NCT01179048)] [54, 55], semaglutide [SUSTAIN-6 (NCT01720446)] [55], albiglutide [Harmony Outcomes (NCT02465515)] [56] and efpeglenatide [AMPLITUDE-O (NCT03496298)] [57]

In the long term, while the immediate costs of providing access to GLP-1s may be high, the potential savings from preventing obesity-related diseases could offset these costs

Tirzepatide (dual GIP/GLP-1RA) was administered to mice in which endometrial tumors had been induced with a cytomegalovirus promoter (58)

At the two-year mark, 77.1% of semaglutide participants maintained at least 5% weight loss versus 34.4% on placebo