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2 Neurological and behavioral models Because GLP-1R agonists cross the blood-brain barrier to influence appetite via hypothalamic signaling and reward pathways, researchers are increasingly interested in how these peptides affect preclinical models related to the central nervous system

Clinical studies consistently demonstrate that semaglutide offers superior results compared to other GLP-1 receptor agonists, such as liraglutide

This perspective provides the basis for subsequent sections examining nicotinamide adenine dinucleotide (phosphate) (NAD(P)H

Several lines of evidence support a role for GIP in GLP-1 secretion

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Chen YH, et al
