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Clinical qualification is required

Metformin is also associated with modest weight loss or weight neutrality, making it suitable for long-term use

Therefore, current prescribing information advises discontinuation before conception

Normal cold sensitivity associated with weight loss during GLP-1 therapy typically presents as: A general feeling of being cooler than before treatment commenced Needing extra layers of clothing or preferring warmer environments Cold hands and feet, particularly in cool weather Symptoms that correlate with the amount of weight lost No other concerning features such as extreme fatigue, confusion, or changes in heart rate These sensations usually stabilise once weight loss plateaus and the body adjusts to its new composition

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