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In this mechanism, ATP-consuming translocation of Ca 2+ into the ER by sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) and the release of Ca 2+ from the ER into the cytosol via the Ca 2+ release channels constitute a potential futile cycle that enhances thermogenic respiration

2.3 Data extraction and risk of bias assessment Two independent reviewers (IR and SK) extracted the following data using a pre-tested form: Author name, publication year, country of origin

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