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GLP-1 Receptor Activation The GLP-1 pathway is the foundation of modern weight loss therapies: Appetite Suppression : Acts on hypothalamic centers to reduce hunger signals Satiety Enhancement : Makes you feel fuller longer with smaller portions Gastric Motility : Slows stomach emptying, prolonging fullness Glucose Control : Stimulates insulin secretion and improves glucose homeostasis This is the mechanism behind semaglutide and tirzepatide's success, but retatrutide adds two additional pathways

CRediT authorship contribution statement Parastoo Asghari: Writing review & editing, Writing original draft, Methodology, Investigation, Conceptualization

Recent data also suggest that some antiinflammatory effects of GLP-1RAs may be centrally mediated even with minimal penetration (218)