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EU recommends updating Wegovy (semaglutide 2.4 mg) label to reflect reduced heart failure symptoms and improved physical function in obesity-related HFpEF, following positive STEP HFpEF trials

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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1