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The PIONEER 6 cardiovascular outcomes trial demonstrated that oral semaglutide was non-inferior to placebo for major adverse cardiovascular events (MACE) in high-risk patients

Constipation is a common side effect experienced by patients taking semaglutide (Ozempic, Wegovy, Rybelsus), affecting 5-24% of users depending on formulation and dose

While berberine is generally well-tolerated at recommended doses, several safety considerations warrant attention

FRC, fixed-ratio combination
