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Developed by Novo Nordisk, semaglutide was first approved for type 2 diabetes in 2017 as Ozempic, then for obesity in 2021 as Wegovy

doi: 10.2337/dc10-2105 19 WangHKuangJXuMGaoZLiQLiuSet al
As good clinical practice, ensuring that thyroid function is adequately controlled with levothyroxine before initiating additional therapies is advisable

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Some of the remaining undigested organic bone matrix is subsequently degraded by collagenases (especially histone K) (Lu et al., 2018)
