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The critical distinction is reversibility and risk profile: Retatrutide is a weekly injection with temporary, manageable side effects versus a permanent surgical intervention with non-trivial operative risk

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Most patients begin noticing reduced inflammation and improved mobility within 12 weeks, with more significant healing and recovery benefits developing over 36 weeks, depending on the condition being treated

In a study by Esmarck et al., immediate post-exercise protein supplementation during a 12-week resistance training program in old men, induced significant quadriceps hypertrophy, whereas delayed supplementation had no effect [48]

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