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Dehydration, caloric restriction, and electrolyte shifts are common contributors
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The inner ring illustrates key downstream signaling pathwaysincluding cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, and ERK/MAPKthat orchestrate mitochondrial biogenesis, antioxidant defenses, proteostasis, autophagy, stress adaptation, and regulation of inflammation
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