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This report highlights the therapeutic potential of GLP-2 analogs in a rodent model of chemotherapy-induced gastrointestinal damage

Massive, but bounded

Large randomized clinical trials have consistently demonstrated that these agents not only improve glycemic control but also significantly reduce rates of cardiovascular death, heart failure hospitalization, and progression of chronic kidney disease [4,5,6]

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Furthermore, offlabel does not mean unsupported by all evidence, but it does mean that the strength of evidence varies widely