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In late-stage type 2 diabetes mellitus (T2DM), impaired islet cell function leads to absolute insulin deficiency, thereby disrupting blood glucose homeostasis

In a recent trial, semaglutide led to a 20% reduction in major adverse cardiovascular events (MACE) in patients []

Despite this being prominent in the news, the first medication mentioned by GPs and IMs when asked Which drugs for managing of patients living with obesity are you aware of, even if you have not prescribed them? was, in 54% of responses, the much older and less effective orlistat and its brand names Xenical and Alli (figure 1)

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