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4.2 Promotion of insulin secretion GLP-1 stimulates insulin secretion in a glucose-dependent manner through specific receptors expressed on pancreatic cells.GLP-1R is a family of secretins (class B) that couples GLP-1 to downstream cell responses, and conformational changes in the receptor upon ligand binding facilitate the interaction between its intracellular region and signaling proteins (Jones et al., 2018)

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Heimburger SM, Bronden A, Johansen NJ, Dejgaard TF, Vilsboll T, Knop FK

Structure of the human glucagon class B G-protein-coupled receptor

52-Week Range $623.78 $1,249.45 Dividend Yield 0.59% P/E Ratio 41.85 Price Target $1,283.64 By all accounts, Eli Lilly's Tirzepatide, the active ingredient in Mounjaro and Zepbound, is superior on paper to Semaglutide, the active ingredient in Ozempic and Wegovy, because it targets two hormones compared to one