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Figure 1 2 MASLDs pathophysiology and current treatment MASLD is characterized by an abnormal accumulation of lipids in hepatocytes, commonly occurring in the context of obesity, insulin resistance, and T2DM-key features of metabolic syndrome that substantially affect patient quality of life and long-term prognosis ( The complex pathophysiology of MASLD calls for integrated, multi-faceted therapeutic regimens and improved diagnostic tools to enhance clinical outcomes

Collagen and elastin fibers can become stretched, damaged or weakened, especially in areas like the abdomen, arms, thighs and lower back, resulting in loose or sagging skin

Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals

Review dose escalation : According to the Ozempic SmPC, treatment is typically initiated at 0.25 mg weekly for four weeks, then increased to 0.5 mg weekly, with further increases to 1 mg or 2 mg if needed

A favorable committee vote still has to be followed by FDA rulemaking, which can take well over a year