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This increase is occurring in all age groups, but most significantly in the adolescent population, and estimated to be around 20.6 % [1]
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A previous meta-analysis 4 found that application of rosiglitazone, a thiazolidinedione (TZD) diabetic drug, could significantly increase the risk of myocardial infarction and death from cardiovascular causes, a concept that has subsequently been proven to be incorrect

see ESM Methods for details)

, Mobarec, J
