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An accumulating body of studies are showing positive potential for using GLP-1s for substance use, said Christian Hendershot, director of clinical research at the USC Institute for Addiction Science in Los Angeles

ATP-sensitive K + channels in vascular mural cells (smooth muscle cells around arterioles and pericytes around capillaries) have previously been shown to play a major role in regulating vascular tone 20

Liraglutide treatment also increased endothelial nitric oxide synthase (eNOS) and reduced intercellular adhesion molecule-1 (ICAM-1) expression in the aortic endothelium of atherogenic mice models ApoE / mice model [60]