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Description
For IBS-like discomfort more broadly, the 2021 American College of Gastroenterology clinical guideline on IBS made a conditional recommendation against the use of probiotics for the treatment of global IBS symptoms, citing very low quality of evidence and substantial heterogeneity across strains, doses, and outcomes.[6] The ACG position is the strongest authoritative reading available

The neurochemical adaptations that underlie craving reduction require time to develop, and impatience during the early treatment period may lead to premature discontinuation
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Researchers can titrate doses and study dose-response relationships

In a recent late-stage clinical trial, people who switched from weekly injectable GLP-1 drugs such as Wegovy or Zepbound to the experimental daily GLP-1 pill orforglipron maintained nearly all the weight loss they experienced over one year
