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10.1002/biof.1406 [DOI] [PubMed] [Google Scholar] Rus GZ, Jansen K, Titus S, Carvalho AF, Gabbay V, Quevedo J (2015) Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies

If pain persists beyond 46 weeks despite conservative care, imaging (X-ray or MRI) may rule out structural changes
